The Bra/Br” Alloantigen System on Human Platelets
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چکیده
Anti-Br was first identified in four cases of neonatal alloimmune thrombocytopenia (NAIT). The antigen Br is localized on the glycoprotein la/Ila complex of platelets. Anti-Br’ can best be detected by a glycoprotein-specific immunoassay using monoclonal antibodies for antigen immobilization (MAIPA assay) and radioimmunoprecipitation (RIP). Recently, we have identified sera from two polytransfused patients that contain an antibody that recognizes Brb, the allele of Br. Family studies show that both
منابع مشابه
The Human Platelet Alloantigens Bra and Brb Are Associated with a Single Amino Acid Polymorphism on Glycoprotein la ( Integrin Subunit a 2 )
The human GPIa/Ila complex, also known as integrin a2Bfl, serves as a major receptor for collagen in platelets and other cell types. In addition to its role in platelet adhesion to extracellular matrix, GPIa/IIa is also known to bear the clinically important Br' and Br' alloantigenic determinants, which can result in antibody-mediated platelet destruction. Immunochemical studies showed that the...
متن کاملThe Bra/Br” Alloantigen System on Human Platelets
Anti-Br was first identified in four cases of neonatal alloimmune thrombocytopenia (NAIT). The antigen Br is localized on the glycoprotein la/Ila complex of platelets. Anti-Br’ can best be detected by a glycoprotein-specific immunoassay using monoclonal antibodies for antigen immobilization (MAIPA assay) and radioimmunoprecipitation (RIP). Recently, we have identified sera from two polytransfus...
متن کاملThe Bra/Br” Alloantigen System on Human Platelets
Anti-Br was first identified in four cases of neonatal alloimmune thrombocytopenia (NAIT). The antigen Br is localized on the glycoprotein la/Ila complex of platelets. Anti-Br’ can best be detected by a glycoprotein-specific immunoassay using monoclonal antibodies for antigen immobilization (MAIPA assay) and radioimmunoprecipitation (RIP). Recently, we have identified sera from two polytransfus...
متن کاملThe Bra/Br” Alloantigen System on Human Platelets
Anti-Br was first identified in four cases of neonatal alloimmune thrombocytopenia (NAIT). The antigen Br is localized on the glycoprotein la/Ila complex of platelets. Anti-Br’ can best be detected by a glycoprotein-specific immunoassay using monoclonal antibodies for antigen immobilization (MAIPA assay) and radioimmunoprecipitation (RIP). Recently, we have identified sera from two polytransfus...
متن کاملThe human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).
The human GPIa/IIa complex, also known as integrin alpha 2 beta 1, serves as a major receptor for collagen in platelets and other cell types. In addition to its role in platelet adhesion to extracellular matrix, GPIa/IIa is also known to bear the clinically important Br(a) and Brb alloantigenic determinants, which can result in antibody-mediated platelet destruction. Immunochemical studies show...
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